Robert williamson scite code#
The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Prediction of the coding sequences of unidentified human genes. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. Cloning, expression and chromosomal mapping of a human ATPase II gene, member of the third subfamily of P-type ATPases and orthologous to the presumed bovine and murine aminophospholipid translocase. High-resolution mapping of human chromosome 11 by in situ hybridization with cosmid clones. University Park, PA: University of Pennsylvania, 1993. MEGA: Molecular Evolutionary Genetics Analysis (version 1.01). Exposure of phosphatidyl-serine is a general feature in the phagocytosis of apoptotic lymphocytes by macrophages. Genome screening by searching for shared segments: mapping a gene for benign recurrent intrahepatic cholestasis. Modes of DAPI banding and simultaneous in situ hybridization.
Multiple members of a third subfamily of P-type ATPases identified by genomic sequences and ESTs. Confidence limits on phylogenies: an approach using the bootstrap. A technique for radiolabeling DNA restriction endonuclease fragments to high specificity. Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages. The complete inventory of the yeast Saccharomyces cerevisiae P-type transport ATPases. A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis. Binding and phagocytosis of apoptotic vascular smooth muscle cells is mediated in part by exposure of phosphatidylserine. An overview of membrane transport proteins in Saccharomyces cerevisiae. These results suggest that the genes are expressed in a tissue-specific manner, are not simply redundant, and may represent isoforms that transport a variety of different amphipaths. With one exception, all of the genes are highly expressed in the central nervous system (CNS) however, the pattern of expression within the CNS differs substantially from gene to gene. The genes are differentially expressed in the respiratory, digestive, and urogenital systems, endocrine organs, the eye, teeth, and thymus. To gain information on the functions represented by these groups, Northern analysis and in situ hybridization were used to examine the pattern of expression of a panel of subfamily members in the mouse. Phylogenetic analysis reveals the genes to be grouped into several distinct classes and subclasses. As reported here, mammals express as many as 17 different genes from this subfamily. Cloning of the gene encoding the enzyme identified a new subfamily of P-type ATPases, proposed to be amphipath transporters. Genomics 1: 139–150, 1999.-The aminophospholipid translocase transports phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to another. Differential expression of putative transbilayer amphipath transporters. Newman, Yoshinobu Nakanishi, Hiroshi Ando, Daniel Weinstock, Patrick Williamson, and Robert A. Lawler, Jr., Seth Blackshaw, Ling Gao, Priya Nagarajan, Coleen Hacker, Scott Pyle, Jason T.
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